Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence

@inproceedings{Wiley2017AnalysisOI,
  title={Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence},
  author={Christopher D. Wiley and James M. Flynn and Christapher S Morrissey and Ronald Lebofsky and Joe Shuga and Xiao Dong and Marc A. Unger and Jan Vijg and Simon Melov and Judith Campisi},
  booktitle={Aging cell},
  year={2017}
}
Senescent cells play important roles in both physiological and pathological processes, including cancer and aging. In all cases, however, senescent cells comprise only a small fraction of tissues. Senescent phenotypes have been studied largely in relatively homogeneous populations of cultured cells. In vivo, senescent cells are generally identified by a small number of markers, but whether and how these markers vary among individual cells is unknown. We therefore utilized a combination of… CONTINUE READING
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A novel biomarker identifies senescent human cells in culture and in aging skin in vivo

  • GP Dimri, X Lee, +9 authors J Campisi
  • Proc. Natl Acad. Sci. USA
  • 1995
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DAVID bioinformatics resources: expanded annotation database and novel algorithms to better extract biology from large gene lists

  • DW Huang, BT Sherman, +8 authors RA Lempicki
  • Nucleic Acids Res
  • 2007
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