Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus.

@article{Manicassamy2010AnalysisOI,
  title={Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus.},
  author={Balaji Manicassamy and Santhakumar Manicassamy and Alan Belicha-Villanueva and Giuseppe Pisanelli and Bali Pulendran and Adolfo Garc{\'i}a-Sastre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 25},
  pages={11531-6}
}
Influenza A virus is being extensively studied because of its major impact on human and animal health. However, the dynamics of influenza virus infection and the cell types infected in vivo are poorly understood. These characteristics are challenging to determine, partly because there is no efficient replication-competent virus expressing an easily traceable reporter gene. Here, we report the generation of a recombinant influenza virus carrying a GFP reporter gene in the NS segment (NS1-GFP… CONTINUE READING
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