Analysis of in Vitro Skin Permeation of 22-Oxacalcitriol Having a Complicated Metabolic Pathway

Abstract

The purpose of this study is to analyze simultaneous skin permeation and metabolism of 22-oxacalcitriol (OCT) having several metabolites in skin by observing skin permeation of only unchanged OCT through excised rat skin. A diffusion model including metabolic processes was employed to express simultaneous skin permeation and metabolism of OCT. In vitro… (More)
DOI: 10.1007/s11095-006-9781-z

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