Analysis of hyaluronic acid in the diagnosis of malignant mesothelioma.

  title={Analysis of hyaluronic acid in the diagnosis of malignant mesothelioma.},
  author={Brian K. Chiu and Andrew Churg and A. Tengblad and Rachel Pearce and W T Mccaughey},
  volume={54 10},
Using a modified papain digestion cetylpyridinium salt precipitation method, glycosaminoglycans were isolated from 21 mesotheliomas, 34 primary lung carcinomas, 12 carcinomas of other sites, and 7 soft tissue sarcomas. Qualitatively, hyaluronic acid (HA) was present in 20 of 21 mesotheliomas, about half of the primary lung adenocarcinomas, and all of the soft tissue sarcomas. On the average, HA constituted 45% of the total glycosaminoglycans in the mesotheliomas and 28% of the total in the lung… CONTINUE READING


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