Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment

@article{Hughes2014AnalysisOH,
  title={Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment},
  author={Jim R. Hughes and Nigel Roberts and Simon J. McGowan and Deborah L Hay and Eleni Giannoulatou and Magnus David Lynch and Marco Gobbi and Stephen Taylor and Richard E. Gibbons and Douglas R Higgs},
  journal={Nature Genetics},
  year={2014},
  volume={46},
  pages={205-212}
}
Gene expression during development and differentiation is regulated in a cell- and stage-specific manner by complex networks of intergenic and intragenic cis-regulatory elements whose numbers and representation in the genome far exceed those of structural genes. Using chromosome conformation capture, it is now possible to analyze in detail the interaction between enhancers, silencers, boundary elements and promoters at individual loci, but these techniques are not readily scalable. Here we… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 27 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
114 Extracted Citations
54 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 114 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…