Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection.

@article{Xi1995AnalysisOH,
  title={Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection.},
  author={Long-fu Xi and Gwendeline Demers and Laura A. Koutsky and Nancy B. Kiviat and Jane Kuypers and D Heather Watts and King K. Holmes and Denise A. Galloway},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={172 3},
  pages={747-55}
}
Sequence differences in the noncoding region of the human papillomavirus type 16 (HPV-16) genome were displayed using single-stranded conformational polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified material. Two variants accounted for 50%-70% of all HPV-16 variants from 3 cohorts in Seattle. Seventy subjects who were repeatedly HPV-16 DNA-positive over 2-8 4-monthly visits showed an identical SSCP pattern at every visit. Only 10%-20% of the specimens showed evidence of… CONTINUE READING

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