Analysis of human immunodeficiency virus type 1 promoter insertion in vivo.

@article{Raineri1995AnalysisOH,
  title={Analysis of human immunodeficiency virus type 1 promoter insertion in vivo.},
  author={Ines Raineri and Muriel Soler and Hansjorg Senn},
  journal={Virology},
  year={1995},
  volume={208 1},
  pages={359-64}
}
Our study reports the occurrence of HIV-1 insertional activation events in vivo. Using a previously described PCR assay, small aliquots of broncho-alveolar lavage (BAL) cells obtained from AIDS patients were analyzed. Nine percent (5/54) of the aliquots contained proviral-host sequence transcripts indicating HIV-1 promoter insertion, whereas multiply spliced HIV-1 mRNAs were found in 28% (15/54) of the aliquots. In four of five events, insertions affect distinct cellular transcription units… CONTINUE READING