Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo.

@article{Hermankova2003AnalysisOH,
  title={Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo.},
  author={Monika Hermankova and Janet D Siliciano and Yan Zhou and Daphne Monie and Karen Chadwick and Joseph B. Margolick and Thomas C Quinn and Robert F. Siliciano},
  journal={Journal of virology},
  year={2003},
  volume={77 13},
  pages={7383-92}
}
In individuals with human immunodeficiency virus type 1 (HIV-1) infection, a small reservoir of resting memory CD4(+) T lymphocytes carrying latent, integrated provirus persists even in patients treated for prolonged periods with highly active antiretroviral therapy (HAART). This reservoir greatly complicates the prospects for eradicating HIV-1 infection with antiretroviral drugs. Therefore, it is critical to understand how HIV-1 latency is established and maintained. In particular, it is… CONTINUE READING

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