Analysis of human cytomegalovirus-encoded microRNA activity during infection.

  title={Analysis of human cytomegalovirus-encoded microRNA activity during infection.},
  author={Noam Stern-Ginossar and Niveen Saleh and Miri D. Goldberg and Mark Prichard and Dana G. Wolf and Ofer Mandelboim},
  journal={Journal of virology},
  volume={83 20},
MicroRNAs (miRNAs) are expressed in a wide variety of organisms, ranging from plants to animals, and are key posttranscriptional regulators of gene expression. Virally encoded miRNAs are unique in that they could potentially target both viral and host genes. Indeed, we have previously demonstrated that a human cytomegalovirus (HCMV)-encoded miRNA, miR-UL112, downregulates the expression of a host immune gene, MICB. Remarkably, it was shown that the same miRNA also downregulates immediate-early… CONTINUE READING


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