Analysis of human P[4]G2 rotavirus strains isolated in Brazil reveals codon usage bias and strong compositional constraints.

@article{Gomez2011AnalysisOH,
  title={Analysis of human P[4]G2 rotavirus strains isolated in Brazil reveals codon usage bias and strong compositional constraints.},
  author={Mariela Gomez and Luis Fernando L{\'o}pez Tort and Eduardo de Mello Volot{\~a}o and Ricardo Recarey and Gonzalo Moratorio and H{\'e}ctor Musto and Jos{\'e} Leite and Juan Cristina},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2011},
  volume={11 3},
  pages={
          580-6
        }
}
The Rotavirus genus belongs to the family Reoviridae and its genome consist of 11 segments of double-stranded RNA. Group A rotaviruses (RV-A) are the main etiological agent of acute viral gastroenteritis in infants and young children worldwide. Understanding the extent and causes of biases in codon usage is essential to the understanding of viral evolution. However, the factors shaping synonymous codon usage bias and nucleotide composition in human RV-A are currently unknown. In order to gain… CONTINUE READING
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