Analysis of glial fibrillary acidic protein gene methylation in human malignant gliomas.

@article{Fukuyama1996AnalysisOG,
  title={Analysis of glial fibrillary acidic protein gene methylation in human malignant gliomas.},
  author={Kayako Fukuyama and Kazuhito Matsuzawa and Sherri Lynn Hubbard and Peter Dirks and Makoto Murakami and James T. Rutka},
  journal={Anticancer research},
  year={1996},
  volume={16 3A},
  pages={1251-7}
}
Glial fibrillary acidic protein (GFAP) is an intermediate filament specifically expressed in glial cells which helps to maintain and stabilize the glial cytoskeleton. Interestingly, with increasing astrocytic anaplasia, there is typically progressive loss of GFAP expression. In in vitro model systems, most permanent glioma cell lines are GFAP-negative. To determine the mechanism by which the transcription of the GFAP gene may be repressed in glioma cell lines, we initially performed a Southern… CONTINUE READING

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