Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.

@article{Naoe2000AnalysisOG,
  title={Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.},
  author={Tomoki Naoe and Kunihiko Takeyama and Tomotsu Yokozawa and Hitoshi Kiyoi and Motoko Seto and Naokuni Uike and Teruo Ino and Atae Utsunomiya and Atsuo Maruta and Iturou Jin-nai and Nanao Kamada and Yoshinobu Kubota and Hiroyuki Nakamura and Chihiro Shimazaki and Shigeo Horiike and Yoshio Kodera and Hiroshi Saito and Ryo Ueda and J Wiemels and Ryuzo Ohno},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 10},
  pages={4091-5}
}
Several genetic polymorphisms in metabolic activation or detoxification enzymes have been associated with susceptibility to therapy-related leukemia and myelodysplastic leukemia (TRLIMDS). We analyzed gene polymorphisms of NAD(P)H:quinone oxidoreductase (NQOl), glutathione S-tranferase (GST)-MI and -TI, and CYP3A4, the enzymes of which are capable of metabolizing anticancer drugs, in 58 patients with TRL/MDS and in 411 patients with de novo acute myeloid leukemia (AML). Homozygous Ser/Ser… CONTINUE READING
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