Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder.

@article{Maciukiewicz2014AnalysisOG,
  title={Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder.},
  author={Malgorzata Maciukiewicz and Monika Dmitrzak-Węglarz and Joanna Maria Pawlak and Anna Leszczyńska-Rodziewicz and Dorota Zaremba and Maria Skibinska and Joanna Hauser},
  journal={Chronobiology international},
  year={2014},
  volume={31 6},
  pages={770-8}
}
Bipolar affective disorder (BD) is a severe psychiatric disorder characterized by periodic changes in mood from depression to mania. Disruptions of biological rhythms increase risk of mood disorders. Because clinical representation of disease is heterogeneous, homogenous sets of patients are suggested to use in the association analyses. In our study, we aimed to apply previously computed structure of bipolar disorder symptom dimension for analyses of genetic association. We based quantitative… CONTINUE READING
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