Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis.

@article{Sugimura1993AnalysisOG,
  title={Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis.},
  author={Kazuro Sugimura and Hitoshi Asakura and Nobuhisa Mizuki and Mitsuko Inoue and Tadaaki Hibi and Akikuni Yagita and Kimiyoshi Tsuji and Hidetoshi Inoko},
  journal={Human immunology},
  year={1993},
  volume={36 2},
  pages={112-8}
}
To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. Significant increase was observed in Bw52, DPw9 (DPB1*0901), and DR2 (DRB1*1502) in Japanese patients with UC. Linkage analysis indicated that A24-Bw52-DR2-DPw9 alleles constitute a common haplotype in… CONTINUE READING
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