Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine.

@article{Liang2002AnalysisOG,
  title={Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine.},
  author={Gangning Liang and Felicidad A. Gonzales and Peter A. Jones and Torben Falck Orntoft and Thomas Thykjaer},
  journal={Cancer research},
  year={2002},
  volume={62 4},
  pages={961-6}
}
Hypermethylation of the promoters of cancer-related genes is often associated with their inactivation during tumorigenesis. Several preclinical and clinical trials have been developed to use DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (5-Aza-CdR) in attempts to reactivate silenced genes in human cancers. We used high-density oligonucleotide gene expression microarrays to examine the effects of 5-Aza-CdR treatment on human fibroblast cells (LD419) and a human bladder tumor cell… CONTINUE READING

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