Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death.

@article{Bossers2009AnalysisOG,
  title={Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death.},
  author={Koen A M Bossers and Gideon F. Meerhoff and Rawien A Balesar and Jeroen W F van Dongen and Chris G. Kruse and Dick F. Swaab and Joost Verhaagen},
  journal={Brain pathology},
  year={2009},
  volume={19 1},
  pages={91-107}
}
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. We have studied alterations in gene expression in the substantia nigra, the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays. To gain insight into changes in gene expression during early stages of dopaminergic neurodegeneration, we selectively investigated the relatively spared parts of… CONTINUE READING

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We identified changes in the expression of 287 transcripts in the substantia nigra , 16 transcripts in the caudate nucleus and four transcripts in the putamen .
We have studied alterations in gene expression in the substantia nigra , the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays .
We have studied alterations in gene expression in the substantia nigra , the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays .
We identified changes in the expression of 287 transcripts in the substantia nigra , 16 transcripts in the caudate nucleus and four transcripts in the putamen .
We identified changes in the expression of 287 transcripts in the substantia nigra , 16 transcripts in the caudate nucleus and four transcripts in the putamen .
We have studied alterations in gene expression in the substantia nigra , the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays .
We identified changes in the expression of 287 transcripts in the substantia nigra , 16 transcripts in the caudate nucleus and four transcripts in the putamen .
We have studied alterations in gene expression in the substantia nigra , the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays .
Parkinson 's disease ( PD ) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra .
We have studied alterations in gene expression in the substantia nigra , the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays .
We identified changes in the expression of 287 transcripts in the substantia nigra , 16 transcripts in the caudate nucleus and four transcripts in the putamen .
We identified changes in the expression of 287 transcripts in the substantia nigra , 16 transcripts in the caudate nucleus and four transcripts in the putamen .
We have studied alterations in gene expression in the substantia nigra , the caudate nucleus and putamen of four PD patients and four matched controls using custom designed Agilent microarrays .
Parkinson 's disease ( PD ) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra .
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