Analysis of functional SNP in ifng/ifngr1 in Chinese Han population with tuberculosis.

  title={Analysis of functional SNP in ifng/ifngr1 in Chinese Han population with tuberculosis.},
  author={Jian-xun He and Jingming Wang and D Lei and Shiping Ding},
  journal={Scandinavian journal of immunology},
  volume={71 6},
Ifng/Ifngr1 are the main genes that are associated with tuberculosis. We continued to search for other functional single nucleotide polymorphisms (SNP) and investigated their influence on patients with tuberculosis in the Chinese population. Seven SNP located in the ifng and ifngr1 genes were genotyped by ligase detection reaction in 222 cases and 188 ethnically matched controls. A significant genetic association between rs7749390 (located on the exon/intron splice site of the ifngr1 gene) and… CONTINUE READING
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