Analysis of four diverse population groups indicates that a subset of cystic fibrosis mutations occur in common among Caucasians.

@article{Cutting1992AnalysisOF,
  title={Analysis of four diverse population groups indicates that a subset of cystic fibrosis mutations occur in common among Caucasians.},
  author={Garry R. Cutting and Sheila M. Curristin and Elizabeth Nash and Beryl J. Rosenstein and Israela Lerer and Dvorah Abeliovich and Alyssa Hill and Colin Graham},
  journal={American journal of human genetics},
  year={1992},
  volume={50 6},
  pages={1185-94}
}
To determine the nature and frequency of non-delta F508 cystic fibrosis (CF) mutations among diverse populations, we have sequenced exons 9-12 and 19-23 of the CF transmembrane conductance regulator (CFTR) gene from 128 CF chromosomes (39 U.S. Caucasian, 27 African-American, 42 Northern Irish, and 20 Israeli chromosomes). These regions were chosen because they encode the two putative ATP-binding folds of CFTR, domains which appear to have functional significance. In addition, CFTR exons 1 and 2… CONTINUE READING

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