Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis.

@article{Gritsun1995AnalysisOF,
  title={Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis.},
  author={Tamara Sergeevna Gritsun and Edward C. Holmes and Ernest Andrew Gould},
  journal={Virus research},
  year={1995},
  volume={35 3},
  pages={307-21}
}
Studies on the molecular basis of flavivirus neutralisation, attenuation and tropism indicate that amino acid substitutions, in different parts of the envelope gene, may be responsible for the altered phenotypes. However, the association of particular substitutions with individual characteristics has proven difficult. Comparative analysis of all known tick-borne flavivirus envelope proteins through sequence alignment and a sliding window, reveals clusters of amino acid variation distributed… CONTINUE READING

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