Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis

Abstract

The identification of Lynch syndrome has been greatly assisted by the advent of tumour immunohistochemistry (IHC) for mismatch repair (MMR) proteins, and by the recognition of the role of acquired somatic BRAF mutation in sporadic MMR-deficient colorectal cancer (CRC). However, somatic BRAF mutation may also be present in the tumours in families with a… (More)
DOI: 10.1007/s10689-009-9238-8

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Cite this paper

@article{Walsh2009AnalysisOF, title={Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis}, author={Michael D. Walsh and Daniel D Buchanan and Rhiannon J. Walters and Aedan Roberts and Sven T Arnold and Diane M. McKeone and Mark Clendenning and Andrew R. Ruszkiewicz and Mark A Jenkins and John L. Hopper and Jack Goldblatt and Jillian M George and Graeme Suthers and Kerry D. Phillips and Graeme P. Young and Finlay A. Macrae and Musa Drini and Michael O. Woods and Susan Parry and Jeremy R. Jass and Joanne P. Young}, journal={Familial Cancer}, year={2009}, volume={8}, pages={313-323} }