Analysis of factors regulating erythrocyte deformability.

@article{Mohandas1980AnalysisOF,
  title={Analysis of factors regulating erythrocyte deformability.},
  author={Narla Mohandas and Michael Ronald Clark and Myron S. Jacobs and Stephen B. Shohet},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={66 3},
  pages={
          563-73
        }
}
Using a laser diffraction technique, we have studied factors that influence the deformability of erythrocytes. Variations in suspending medium osmolality and applied shear stress were employed to isolate the individual contributions to whole cell deformability of internal viscosity, surface area-to-volume ratio, and viscoelastic properties of the membrane. An experimental system was devised in which normal cells were modified in vitro to induce specific alterations in each factor. Measurements… CONTINUE READING

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