Analysis of factorial time-course microarrays with application to a clinical study of burn injury.

  title={Analysis of factorial time-course microarrays with application to a clinical study of burn injury.},
  author={Baiyu Zhou and Weihong Xu and David N . Herndon and Ronald G. Tompkins and Ronald W. Davis and Wenzhong Xiao and Wing Hung Wong and Mehmet Toner and H. Shaw Warren and David A. Schoenfeld and Laurence G Rahme and Grace P. McDonald-Smith and Douglas L. Hayden and Philip H. Mason and Shawn Fagan and Yong-ming Yu and Daniel G Remick and John A. Mannick and James A. Lederer and Richard L. Gamelli and Geoffrey M Silver and Michael B Shapiro and Richard Smith and David G. Camp and Weijun Qian and John D. Storey and Michael N. Mindrinos and Rob Tibshirani and Stephen F. Lowry and Steven E. Calvano and Irshad I Chaudry and Michael A. West and Mitchell H. Cohen and Ernest Eugene Moore and Jeffrey R. Johnson and Lyle L. Moldawer and Henry V Baker and Philip Alexander Efron and Ulysses J. Balis and Timothy R Billiar and Juan B. Ochoa and Jason Lee Sperry and Carol L. Miller-Graziano and Asit K. De and Paul E. Bankey and Celeste C. Finnerty and Marc Gerhard Jeschke and Joseph P. Minei and Brett D. Arnoldo and John Hunt and Jureta Horton and J. Perren Cobb and Bernard H. Brownstein and Bradley Freeman and Ronald V. Maier and Avery B Nathens and Joseph Cuschieri and Nicole S. Gibran and Matthew Brady Klein and Grant E O'keefe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 22},
Time-course microarray experiments are capable of capturing dynamic gene expression profiles. It is important to study how these dynamic profiles depend on the multiple factors that characterize the experimental condition under which the time course is observed. Analytic methods are needed to simultaneously handle the time course and factorial structure in the data. We developed a method to evaluate factor effects by pooling information across the time course while accounting for multiple… CONTINUE READING