Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis.

@article{Ni2001AnalysisOE,
  title={Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis.},
  author={Hongyu Ni and Melek Ergin and Qin Huang and J Z Qin and Hesham M. Amin and Robert L Martinez and Shehzad Ahmed Saeed and Kevin A. Barton and Serhan Alkan},
  journal={British journal of haematology},
  year={2001},
  volume={115 2},
  pages={279-86}
}
Nuclear factor-kappa B (NF-kappa B) is an important transcription factor that regulates survival in many cells. Activated NF-kappa B has been shown to protect some haematopoietic neoplastic cells from apoptosis. In the present study, we analysed NF-kappa B status in 13 primary samples from patients with multiple myeloma (MM) and in four myeloma cell lines including U266, RPMI 8226, HS-Sultan and K620. Constitutive activation of NF-kappa B was evaluated by either immunohistochemistry or… CONTINUE READING

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