Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies.

@article{Hitomi2003AnalysisOE,
  title={Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies.},
  author={Kiyotaka Hitomi and Richard B. Presland and Tomomi Nakayama and Philip H Fleckman and Beverly A. Dale and Masatoshi Maki},
  journal={Journal of dermatological science},
  year={2003},
  volume={32 2},
  pages={95-103}
}
BACKGROUND Epidermal-type transglutaminase (TGase 3) is involved in the cross-linking of structural proteins in the epidermis, which results in the formation of the cornified envelope. TGase 3 is activated by limited proteolysis of a 77 kDa zymogen during keratinocyte differentiation. OBJECTIVE To characterize the expression of TGase 3 in human epidermis and cultured keratinocytes, we established specific monoclonal antibodies against the TGase 3. METHODS Recombinant proteins for human… CONTINUE READING

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