Analysis of effector mechanisms against HTLV-I- and HTLV-III/LAV-infected lymphoid cells.

@article{Ruscetti1986AnalysisOE,
  title={Analysis of effector mechanisms against HTLV-I- and HTLV-III/LAV-infected lymphoid cells.},
  author={Francis W. Ruscetti and Judy A. Mikovits and Vaniambadi S. Kalyanaraman and R G Overton and Heather Stevenson and K. Stromberg and Ronald B. Herberman and William L. Farrar and John R. Ortaldo},
  journal={Journal of immunology},
  year={1986},
  volume={136 10},
  pages={3619-24}
}
Acquired immunodeficiency syndrome is associated with a viral (HTLV-III/LAV)-mediated progressive depletion of a helper/inducer T4+ T cell subset, whereas acute T cell leukemia is associated with a viral (HTLV-I)-mediated growth of the same T cell subset. Because large granular lymphocytes (LGL) with natural killer (NK) activity have been shown to spontaneously lyse several virus-infected target cells, the ability of NK cells to lyse both HTLV-I- and HTLV-III/LAV-infected lymphoid cell lines… CONTINUE READING