Corpus ID: 103587872

Analysis of drug resistance and the role of the stem cell niche in leukaemia

@inproceedings{Bakker2017AnalysisOD,
  title={Analysis of drug resistance and the role of the stem cell niche in leukaemia},
  author={E. Bakker},
  year={2017}
}
Glucocorticoids and etoposide are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoblasts through the glucocorticoid receptor (GR) and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution of the bone marrow microenvironment to drug response/resistance all require investigation. Using microenvironment-mimicking conditioned media (CM), dexamethasone (a synthetic glucocorticoid) and etoposide to treat glucocorticoid-sensitive (C7-14… Expand

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