Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose

  title={Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose},
  author={Krishna C. Persaud and George H. Dodd},
Olfaction exhibits both high sensitivity for odours and high discrimination between them1. We suggest that to make fine discriminations between complex odorant mixtures containing varying ratios of odorants without the necessity for highly specialized peripheral receptors, the olfactory systems makes use of feature detection using broadly tuned receptor cells organized in a convergent neurone pathway. As a test of this hypothesis we have constructed an electronic nose using semiconductor… Expand
Representation of Odor Information in the Olfactory System: From Biology to an Artificial Nose
This paper describes how physiological aspects of the processes that underlie how odors are encoded at each level in the olfactory pathway in the brain are characterized in biological experiments, captured in a computational model, and then used to design and build a biologically inspired artificial device. Expand
Detection and classification of natural odors with an in vivo bioelectronic nose.
This novel brain-machine interface using rat's olfaction presents a promising method for odor detection and discrimination, and it is the first step towards in vivo bioelectronic nose equipped with biological olfactory and artificial devices. Expand
Testing olfactory models with an artificial experimental platform
Artificial olfaction systems have been investigated since more than two decades on alleged property of similarities between the receptive field of natural receptors and artificial sensors. Due to theExpand
Spike encoding of artificial olfactory sensor signals
An attempt to introduce artificial noses more adherent to recent views on olfaction is presented and the typical methodology of translation of conventional analog sensor signals into biologically similar spikes is applied to chemical sensors. Expand
Principles of odor coding in vertebrates and artificial chemosensory systems.
An up-to-date overview of the current knowledge of both fields is provided and it is hoped this review will be a breeding ground for better information, communication, and data exchange between very related but so far little connected fields. Expand
An odor discrimination model with application to kin recognition in social insects.
A model for the process of odor discrimination is presented, which hypothesizes neural processing capabilities that include the logarithmic transformations of electrical potentials to generate a scalar quantity representing the "similarity" of two multivalued signals and quantifies the notion of phenotype matching. Expand
An olfactory neuronal network for vapor recognition in an artificial nose
A biologically based neuronal network based directly on neural circuits of the vertebrate olfactory system is implemented in an artificial chemosensing system, enabling discrimination among organic vapors over a range of input signal intensities. Expand
Odor Discrimination Using Cell-Based Odor Biosensor System With Fluorescent Image Processing
Odorants were discriminated using an odor biosensor system with cells expressing different types of olfactory receptors to suggest that the combination of a biosensor and image processing technique has the potential to discriminate between different odorants even if the cells are placed at random. Expand
Exploring olfactory population coding using an artificial olfactory system.
These devices provide support for the hypothesis that a system using an array of cross-reactive sensors is capable of molecular recognition and discrimination, and suggest a number of testable hypotheses about various aspects of odorant coding in the biological olfactory system. Expand
Characterizing complex chemosensors: information-theoretic analysis of olfactory systems
Information theory, which quantifies explicitly the extent to which the world of one system relates to the state of another, can serve as a basis for analysing both natural and engineered odor sensors and can be used to explore the problems of defining stimulus dimensions, assessing strategies of neuronal processing, and examining the properties of biological systems that emerge from interactions among their complex components. Expand


Any attempt to devise a qualitative and quantitative analog for the receptor surface can at this time be approached only by constructing detector mechanisms which display differential adsorption properties for various odorant compounds or detectors which depend on some physical chemical change at the detector surface which can be translated into an electrical signal. Expand
A chemical-modification approach to the olfactory code. Studies with a thiol-specific reagent.
The effects of thiol-specific reagents on the amplitude of the electro-olfactogram (E.O.G.G.) responses elicited from frog olfactory mucosa by pulses of odorant vapours was studied and it is suggested that theOlfactory code at this level of the Olfactory system may be elucidated by chemical-modification methods. Expand
Small molecule-lipid membrane interactions and the puncturing theory of olfaction.
It is found that short-chain alcohols decrease the bilayer resistance, while above C 8 the bilayers resistance is increased, and it is proposed that changes in the fluidity of the lipid hydrocarbon chains are to blame. Expand
Polar vapour detector based on thermal modulation of contact potential
A sensitive, variable-temperature contact-potential device based on the Kelvin-Zisman method was constructed. Its use as a detector of polar vapours was demonstrated. Thermal pulsing of one plate ofExpand
The Determination of Phenolphthalein in Mineral Oil Emulsion
A volumetric method based on the iodination of phenolphthalein in an alkaline medium has been applied to the assay for that compound in emulsions. The emulsion is broken by the addition of anExpand
InP-Langmuir-film m.i.s. structures
The electrical properties of m.i.s. structures based on InP and Langmuir films have been investigated. A strongly inverted low-frequency-type C/V response occurs at about 30 Hz. Surface-stateExpand
Adaptive Information Processing
  • J. Sampson
  • Computer Science
  • Texts and Monographs in Computer Science
  • 1976