Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity.

@article{Zeaiter2008AnalysisOD,
  title={Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity.},
  author={Zaher Zeaiter and David Jacques Cohen and Anne M{\"u}sch and Fabio Bagnoli and Antonello Covacci and Markus Stein},
  journal={Cellular microbiology},
  year={2008},
  volume={10 3},
  pages={781-94}
}
Detergent-resistant membranes of eukaryotic cells are enriched in many important cellular signalling molecules and frequently targeted by bacterial pathogens. To learn more about pathogenic mechanisms of Helicobacter pylori and to elucidate novel effects on host epithelial cells, we investigated how bacterial co-cultivation changes the protein composition of detergent-resistant membranes of gastric adenocarcinoma (AGS) tissue culture cells. Using iTRAQ (isobaric tags for relative and absolute… CONTINUE READING