Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes.

@article{Kowalczyk1996AnalysisOD,
  title={Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes.},
  author={Andrew Kowalczyk and Jeffrey E. Borgwardt and Kathleen Janee Green},
  journal={The Journal of investigative dermatology},
  year={1996},
  volume={107 3},
  pages={293-300}
}
Desmosomes are intercellular adhesive junctions that associate with the intermediate filament cytoskeleton. The two major classes of transmembrane desmosomal glycoproteins, desmogleins and desmocollins, are widely considered to function as adhesion molecules. This assumption is based in part on their homology to the cadherin family of calcium-dependent homophilic adhesion molecules. In addition, autoantibodies from pemphigus patients bind directly to desmoglein family members and are thought to… CONTINUE READING