Analysis of conserved noncoding DNA in Drosophila reveals similar constraints in intergenic and intronic sequences.

@article{Bergman2001AnalysisOC,
  title={Analysis of conserved noncoding DNA in Drosophila reveals similar constraints in intergenic and intronic sequences.},
  author={Casey M. Bergman and Martin Kreitman},
  journal={Genome research},
  year={2001},
  volume={11 8},
  pages={1335-45}
}
Comparative genomic approaches to gene and cis-regulatory prediction are based on the principle that differential DNA sequence conservation reflects variation in functional constraint. Using this principle, we analyze noncoding sequence conservation in Drosophila for 40 loci with known or suspected cis-regulatory function encompassing >100 kb of DNA. We estimate the fraction of noncoding DNA conserved in both intergenic and intronic regions and describe the length distribution of ungapped… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 103 extracted citations

Similar Papers

Loading similar papers…