Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.

@article{DeKoter2007AnalysisOC,
  title={Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.},
  author={Rodney P DeKoter and Meghana B. Kamath and Isaac B. Houston},
  journal={Blood cells, molecules & diseases},
  year={2007},
  volume={39 3},
  pages={316-20}
}
The Ets family transcription factor PU.1, encoded by the gene Sfpi1, is essential for normal hematopoiesis. A number of studies have suggested that changes in PU.1 concentration play a role in directing cell fate decisions during hematopoiesis. However, the stages of hematopoietic development at which changes in PU.1 concentration are important have not been defined until recently. Experiments using conditional null alleles, reporter alleles, and hypomorphic alleles of the Sfpi1 gene in mice… CONTINUE READING