Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever.

@article{Rstemolu2011AnalysisOC,
  title={Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever.},
  author={Aydın R{\"u}stemoğlu and Guvem Gumus-Akay and Serb{\"u}lent Yiğit and Turker Tasliyurt},
  journal={Genetics and molecular research : GMR},
  year={2011},
  volume={10 4},
  pages={3411-20}
}
The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV). However, about one-third of FMF patients have only one mutated allele, suggesting that this disease is expressed as… CONTINUE READING