Analysis of colorectal cancer by comparative genomic hybridization: evidence for induction of the metastatic phenotype by loss of tumor suppressor genes.

@article{ParedesZaglul1998AnalysisOC,
  title={Analysis of colorectal cancer by comparative genomic hybridization: evidence for induction of the metastatic phenotype by loss of tumor suppressor genes.},
  author={A Paredes-Zaglul and Jason Jong-Ho Kang and Y P Essig and Weiqun Mao and Rosalyn B. Irby and Marek Wloch and Timothy J. Yeatman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 4},
  pages={879-86}
}
Current models suggest that colon cancer initiation and progression are secondary to both the activation of oncogenes and the deletion of tumor suppressor genes. The role of each, however, is still poorly understood, particularly with regard to the induction of metastasis. We hypothesized that genetic differences exist between tumors that metastasize distantly and those that do not, and that oncogenes and tumor suppressor genes participate equally in this process. To address this hypothesis… CONTINUE READING
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