Analysis of colchicine-induced chromosomal aberrations in embryos obtained from XO mice.

A high incidence of chromosomal anomalies has been observed in the offspring of our XO mouse colony. However, the reason(s) are unknown. We hypothesized that XO dams might be more susceptible to certain chromosomal mutagens. Therefore, we assessed whether the oocytes of XO mice are more susceptible to colchicine. Pregnant XO and XX mice were… CONTINUE READING