Analysis of clustered point mutations in the human ribosomal RNA gene promoter by transient expression in vivo.

@article{Jones1988AnalysisOC,
  title={Analysis of clustered point mutations in the human ribosomal RNA gene promoter by transient expression in vivo.},
  author={Martin Hugh Jones and R M Learned and Robert Tjian},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 3},
  pages={669-73}
}
We have mapped the cis regulatory elements required in vivo for initiation at the human rRNA promoter by RNA polymerase I. Transient expression in COS-7 cells was used to evaluate the transcription phenotype of clustered base substitution mutations in the human rRNA promoter. The promoter consists of two major elements: a large upstream region, composed of… CONTINUE READING