Analysis of cloned T cell function. II. Differential blockade of various cloned T cell functions by cyclosporine.

Abstract

Cyclosporine has profound suppressive effects on selected in vitro functions of cloned T lymphocytes. Cyclosporine inhibits the antigen-induced proliferation of the helper T cell clone 12-11. The effective dose required to reduce this response by 50% (ED50) is 28 ng/ml. In contrast, the proliferation of clone 12-11 induced by exogenous growth factors in… (More)

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Cite this paper

@article{Orosz1983AnalysisOC, title={Analysis of cloned T cell function. II. Differential blockade of various cloned T cell functions by cyclosporine.}, author={Charles G. Orosz and Derry Charles Roopenian and Mariana Widmer and Francis Bach}, journal={Transplantation}, year={1983}, volume={36 6}, pages={706-11} }