Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.

@article{Huang2004AnalysisOC,
  title={Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.},
  author={Fangtian Huang and Anastasia Khvorova and William L. Marshall and Alexander Sorkin},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 16},
  pages={
          16657-61
        }
}
To identify proteins that participate in clathrin-mediated endocytosis of the epidermal growth factor receptor (EGFR), 13 endocytic proteins were depleted in HeLa cells using highly efficient small interfering RNAs that were designed using a novel selection algorithm. The effects of small interfering RNAs on the ligand-induced endocytosis of EGFR were compared with those effects on the constitutive internalization of the transferrin receptor. The knock-downs of clathrin heavy chain and dynamin… CONTINUE READING
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