Analysis of circulating tumor DNA to monitor metastatic breast cancer.

  title={Analysis of circulating tumor DNA to monitor metastatic breast cancer.},
  author={Sarah-Jane Dawson and Dana Wai Yi Tsui and Muhammed Murtaza and Heather Biggs and Oscar M. Rueda and Suet-Feung Chin and Mark J. Dunning and Davina Gale and Tim Forshew and Betania Mahler-Araujo and Sabrina Rajan and Sean J. Humphray and Jennifer Becq and David J. Halsall and Matthew G. Wallis and D. R. Bentley and Carlos Caldas and Nitzan Rosenfeld},
  journal={The New England journal of medicine},
  volume={368 13},
BACKGROUND The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating tumor DNA) has not been extensively investigated or compared with other circulating biomarkers in breast cancer. METHODS We compared the… 

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