Analysis of circulating populations of Plasmodium falciparum in mild and severe malaria in two different epidemiological patterns in Madagascar.

@article{Durand2008AnalysisOC,
  title={Analysis of circulating populations of Plasmodium falciparum in mild and severe malaria in two different epidemiological patterns in Madagascar.},
  author={R{\'e}my Durand and Fr{\'e}d{\'e}ric Ariey and Sandrine Cojean and Arnaud M Fontanet and Louise Henriette Ranaivo and L Ranarivelo and Jeanne Aim{\'e}e Vonimpaisomihanta and Didier M{\'e}nard and Virginio Pietra and Jacques Le bras and David Laurence Modiano and Milijaona Randrianarivelojosia},
  journal={Tropical medicine & international health : TM & IH},
  year={2008},
  volume={13 11},
  pages={1392-9}
}
OBJECTIVE To investigate whether the severity of Plasmodium falciparum attack in endemic areas was associated with the multiplicity of infection (MOI) and/or with a particular genotype(s). METHOD In two areas of different malaria transmission pattern in Madagascar (Sainte-Marie - mesoendemic and Tsiroanomandidy - hypoendemic) the number and the proportions of msp-2 genotypes within isolates were determined for each patient using a capillary electrophoresis genotyping method. DNA sequencing… CONTINUE READING
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