Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study.

@article{Wedzicha2013AnalysisOC,
  title={Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study.},
  author={Jadwiga A Wedzicha and Marc L A Decramer and Joachim H. Ficker and Dennis E. Niewoehner and Thomas Sandstr{\"o}m and Angel Fowler Taylor and Peter D'Andrea and Christie Arrasate and Hungta Chen and Donald D Banerji},
  journal={The Lancet. Respiratory medicine},
  year={2013},
  volume={1 3},
  pages={
          199-209
        }
}
BACKGROUND We evaluated the effect of dual, longacting inhaled bronchodilator treatment on exacerbations in patients with severe and very severe chronic obstructive pulmonary disease (COPD). METHODS In this parallel-group study, 2224 patients (aged ≥40 years, Global Initiative for Chronic Obstructive Lung Disease stages III-IV, and one or more moderate COPD exacerbation in the past year) were randomly assigned (1:1:1; via interactive voice response or web system; stratified for smoking status… CONTINUE READING
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