Analysis of chromosome aberrations by FISH and Giemsa assays in lymphocytes of cancer patients undergoing whole-body irradiation: comparison of in vivo and in vitro irradiation.

@article{Vorobtsova2001AnalysisOC,
  title={Analysis of chromosome aberrations by FISH and Giemsa assays in lymphocytes of cancer patients undergoing whole-body irradiation: comparison of in vivo and in vitro irradiation.},
  author={Irina Vorobtsova and Firouz Darroudi and Andrey Semyonov and A Kanayeva and N Timofeyeva and Tatyana Yakovleva and Gennady M. Zharinov and Adayapalam Tyagarajan Natarajan},
  journal={International journal of radiation biology},
  year={2001},
  volume={77 11},
  pages={1123-31}
}
PURPOSE To study the cytogenetic effects of fractionated radiotherapy in peripheral blood lymphocytes of five cancer patients. In vitro experiments were performed in parallel using the same dose range and a comparison was made of the induced frequencies of stable and unstable chromosome aberrations. The object was to clarify the use of an in vitro calibration curve for immediate and retrospective dosimetry in cases of radiation accidents. MATERIALS AND METHODS Patients were exposed to 60Co… CONTINUE READING