Analysis of chromosomal alterations induced by asbestos and ceramic fibers.

@article{Dopp1998AnalysisOC,
  title={Analysis of chromosomal alterations induced by asbestos and ceramic fibers.},
  author={Elke Dopp and Dietmar Schiffmann},
  journal={Toxicology letters},
  year={1998},
  volume={96-97},
  pages={155-62}
}
Asbestos and other mineral fibers have long been known as carcinogenic agents. However, the primary mechanisms of fiber-induced carcinogenesis still remain unclear. We have investigated mitotic disturbances caused by amosite, crocidolite, and chrysotile in Syrian hamster embryo (SHE) fibroblasts. We also analyzed micronucleus formation as a result of mitotic disturbances, and carried out a characterization of the induced micronucleus population by kinetochore staining. In addition, the spindle… CONTINUE READING