Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart.

@article{Dibb2007AnalysisOC,
  title={Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart.},
  author={Katharine M Dibb and Helen K. Graham and Luigi A. Venetucci and David J. Eisner and Andrew W. Trafford},
  journal={Cell calcium},
  year={2007},
  volume={42 4-5},
  pages={503-12}
}
Central to controlling intracellular calcium concentration ([Ca(2+)](i)) are a number of Ca(2+) transporters and channels with the L-type Ca(2+) channel, Na(+)-Ca(2+) exchanger and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) being of particular note in the heart. This review concentrates on the regulation of [Ca(2+)](i) in cardiac muscle and the homeostatic mechanisms employed to ensure that the heart can operate under steady-state conditions on a beat by beat basis. To this end we discuss the… CONTINUE READING

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