Analysis of cell-based RNAi screens

@article{Boutros2006AnalysisOC,
  title={Analysis of cell-based RNAi screens},
  author={Michael Boutros and L{\'i}gia P Br{\'a}s and Wolfgang Huber},
  journal={Genome Biology},
  year={2006},
  volume={7},
  pages={R66 - R66}
}
RNA interference (RNAi) screening is a powerful technology for functional characterization of biological pathways. Interpretation of RNAi screens requires computational and statistical analysis techniques. We describe a method that integrates all steps to generate a scored phenotype list from raw data. It is implemented in an open-source Bioconductor/R package, cellHTS ( http://www.dkfz.de/signaling/cellHTS ). The method is useful for the analysis and documentation of individual RNAi screens… CONTINUE READING

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