Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period

@article{Berrendero1999AnalysisOC,
  title={Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period},
  author={Fernando Berrendero and Nunzio Sepe and Jos{\'e} Antonio Ramos and Vincenzo Di Marzo and Jos{\'e} Javier Fern{\'a}ndez-Ruiz},
  journal={Synapse},
  year={1999},
  volume={33}
}
Cannabinoid CB1 receptors emerge early in the rat brain during prenatal development, supporting their potential participation in events related to neural development. In the present investigation, we completed earlier studies, analyzing CB1 receptor binding and mRNA expression by using autoradiography and in situ hybridization, respectively, in the brain of rat fetuses at gestational day (GD) 21 and of newborns at postnatal days (PND) 1 and 5, in comparison with the adult brain. These analyses… 

Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain

Early pattern of expression of functionally active cannabinoid receptors, along with the transient and atypical localization of these proteins in white matter areas during the prenatal stages, suggest an specific role of the endocannabinoid system in the events related to human neural development.

Autoradiographic Study of Pre- and Postnatal Distribution of Cannabinoid Receptors in Human Brain

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Cannabinoid receptor type 1 expression during postnatal development of the rat retina

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Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system.

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Atypical location of cannabinoid receptors in white matter areas during rat brain development

The results indicated that specific binding for cannabinoid receptors can be detected in the brain of rat fetuses at GD21 in the classic areas that contain these receptors in adulthood, and the existence of a transient period of the brain development in the rat, around the last days of the fetal period and the first days of postnatal life, in which CB1 receptors appear located in neuronal fiber‐enriched areas.

Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development.

The view is supported that the system constituted by these receptors and their putative endogenous ligands might play a role in specific molecular events of the brain development, and that CB1 receptor sub type is located in neuronal cells obtained from fetal brain, although preliminary evidence is provided of the existence of another receptor subtype operative in glial cells obtainedfrom the cerebral cortex.

Developmental expression of cannabinoid receptor mRNA.

The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling.

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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
The results suggest that cannabinoid receptors in the embryo are coupled to inhibitory guanine nucleotide binding proteins, and many of the adverse effects of cannabinoids observed during pregnancy could be mediated via these cannabinoid receptors.

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