Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.

@article{Lewis2010AnalysisOC,
  title={Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.},
  author={Joshua P. Lewis and Nicholette D. Palmer and Jennifer B Ellington and Jasmin Divers and Maggie C Y Ng and Lingyi Lu and Carl D. Langefeld and Barry I. Freedman and Donald W. Bowden},
  journal={Genomics},
  year={2010},
  volume={96 4},
  pages={211-9}
}
Chromosome 20q12-q13.1 has been linked to type 2 diabetes (T2D) in multiple populations. We examined the influence of genes in this region on T2D and BMI in two European American case-control populations. SNPs were genotyped in 300 diabetic patients and 310 controls. A subset of 72 SNPs were further genotyped in 470 cases and 442 controls. All genes examined showed evidence of association with T2D in the initial sample (additive P-value [P(a)]=0.00090-0.045). SNPs near PREX1 were also… CONTINUE READING
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