Analysis of buprenorphine and its N-dealkylated metabolite in plasma and urine by selected-ion monitoring.

@article{Blom1985AnalysisOB,
  title={Analysis of buprenorphine and its N-dealkylated metabolite in plasma and urine by selected-ion monitoring.},
  author={Y Blom and U. G. Bondesson and Erik E Angg{\aa}rd},
  journal={Journal of chromatography},
  year={1985},
  volume={338 1},
  pages={89-98}
}
A selected-ion monitoring method was developed for determination of buprenorphine and its N-dealkylated metabolite (norbuprenorphine) in human plasma and urine. N-Propylnorbuprenorphine was added as internal standard to 2-3 ml of sample and the alkaloids were extracted with toluene-2 butanol at pH 9.4. After back-extraction in dilute sulphuric acid, the compounds were heated at 110 degrees C. This procedure led to quantitative loss of methanol followed by ring formation between the 6-methoxy… CONTINUE READING

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