Analysis of buprenorphine, norbuprenorphine, and their glucuronides in urine by liquid chromatography-mass spectrometry.

@article{Kronstrand2003AnalysisOB,
  title={Analysis of buprenorphine, norbuprenorphine, and their glucuronides in urine by liquid chromatography-mass spectrometry.},
  author={Robert Kronstrand and Tor Seld{\'e}n and Martin Josefsson},
  journal={Journal of analytical toxicology},
  year={2003},
  volume={27 7},
  pages={
          464-70
        }
}
Buprenorphine is used for the treatment of chronic pain and also in treatment of heroin addiction as an alternative to methadone. As the availability of buprenorphine increases, so does the risk for abuse and the pressure on forensic and clinical laboratories to analyze for it. Buprenorphine and its dealkylated metabolite are excreted in urine, almost exclusively as glucuronides. The aim of the present study was to evaluate electrospray liquid chromatography tandem mass spectrometry (LC-MS-MS… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

a report on 20 fatalities

A. Tracqui, P. Kintz, B. Ludes. Buprenorphine-related deaths among drug add France
  • J. Anal. Toxicol. 22" 430-434
  • 1998
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

A new series of 13 buprenorphine-related deaths.

  • Clinical biochemistry
  • 2002
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Analysis of buprenorphine in urine specimens.

  • Journal of forensic sciences
  • 1992
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Kintz A new series of 13 buprenorphine - related deaths

P. Lafolie Lin, O. Beck
  • Clin . Biochem .
  • 2002