Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies.


BACKGROUND We investigated the frequency of RAVs among patients failing to achieve SVR in two clinical trials. We also investigated the impact of interferon responsiveness on RAVs and specific baseline RAVs relationship with boceprevir treatment failure. METHODS Data are from 1020 patients enrolled into either SPRINT-2 or RESPOND-2; patients received a 4… (More)
DOI: 10.1016/j.virol.2013.06.029