Analysis of bile acid glutathione thioesters by liquid chromatography/electrospray ionization-tandem mass spectrometry.

@article{Mitamura2007AnalysisOB,
  title={Analysis of bile acid glutathione thioesters by liquid chromatography/electrospray ionization-tandem mass spectrometry.},
  author={Kuniko Mitamura and Mitsuru Sogabe and Hironori Sakanashi and Saai Watanabe and Toshihiro Sakai and Yoshihiro Yamaguchi and Tateaki Wakamiya and Shigeo Ikegawa},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2007},
  volume={855 1},
  pages={
          88-97
        }
}
The formation of thioester-linked glutathione (GSH) conjugates of bile acids (BAs) is presumed to occur via trans-acylation reactions between GSH and reactive acyl-linked metabolites of BAs. The present study examines the chemical reactivity of cholyl-adenylate and cholyl-CoA thioester, acyl-linked metabolites of cholic acid (CA), with GSH to form CA-GSH conjugate in vitro. The authentic specimen of CA-GSH was synthesized along with GSH conjugates of four common BAs found in the human body… CONTINUE READING
BETA

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